User profiles for Duc M. Duong
Duc Minh DuongCore Director III Integrated Proteomics Core, Emory University Verified email at emory.edu Cited by 14202 |
[HTML][HTML] Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on
protein substrates. Whereas K48-linked chains are well established as mediators of …
protein substrates. Whereas K48-linked chains are well established as mediators of …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
[HTML][HTML] Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum* S
…, J Rush, E Ramm, MA Schlager, DM Duong… - Molecular & cellular …, 2006 - ASBMB
The postsynaptic density (PSD) of central excitatory synapses is essential for postsynaptic
signaling, and its components are heterogeneous among different neuronal subtypes and …
signaling, and its components are heterogeneous among different neuronal subtypes and …
[HTML][HTML] Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry
The postsynaptic density (PSD) of central excitatory synapses plays a key role in postsynaptic
signal transduction and contains a high concentration of glutamate receptors and …
signal transduction and contains a high concentration of glutamate receptors and …
[HTML][HTML] TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
…, M Sayegh, PG Donlin-Asp, YH Chen, DM Duong… - Nature …, 2018 - nature.com
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
[HTML][HTML] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease
Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …
[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease
Here, we report proteomic analyses of 129 human cortical tissues to define changes associated
with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network …
with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network …
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease
Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a
common feature of numerous aging-related neurodegenerative diseases, including …
common feature of numerous aging-related neurodegenerative diseases, including …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer’s
disease (AD) 1 , 2 , but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD) 1 , 2 , but how these loci confer AD risk is unclear. Here, we aimed to identify loci …