User profiles for Duc M. Duong

Duc Minh Duong

Core Director III Integrated Proteomics Core, Emory University
Verified email at emory.edu
Cited by 14202

[HTML][HTML] Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

P Xu, DM Duong, NT Seyfried, D Cheng, Y Xie… - Cell, 2009 - cell.com
All seven lysine residues in ubiquitin contribute to the synthesis of polyubiquitin chains on
protein substrates. Whereas K48-linked chains are well established as mediators of …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

…, EB Dammer, DM Duong, L Ping, M Zhou… - Nature medicine, 2020 - nature.com
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level

ECB Johnson, EK Carter, EB Dammer, DM Duong… - Nature …, 2022 - nature.com
The biological processes that are disrupted in the Alzheimer’s disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …

[HTML][HTML] Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum* S

…, J Rush, E Ramm, MA Schlager, DM Duong… - Molecular & cellular …, 2006 - ASBMB
The postsynaptic density (PSD) of central excitatory synapses is essential for postsynaptic
signaling, and its components are heterogeneous among different neuronal subtypes and …

[HTML][HTML] Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry

…, D Cheng, DM Duong, SP Gygi, M Sheng - Journal of Biological …, 2004 - ASBMB
The postsynaptic density (PSD) of central excitatory synapses plays a key role in postsynaptic
signal transduction and contains a high concentration of glutamate receptors and …

[HTML][HTML] TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

…, M Sayegh, PG Donlin-Asp, YH Chen, DM Duong… - Nature …, 2018 - nature.com
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …

[HTML][HTML] Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease

…, CM Watson, BA Gordon, L Ping, DM Duong… - Nature medicine, 2023 - nature.com
Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive
symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques …

[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease

…, EB Dammer, V Swarup, D Nandakumar, DM Duong… - Cell systems, 2017 - cell.com
Here, we report proteomic analyses of 129 human cortical tissues to define changes associated
with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network …

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

…, M Song, X Liu, SS Kang, IS Kwon, DM Duong… - Nature medicine, 2014 - nature.com
Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a
common feature of numerous aging-related neurodegenerative diseases, including …

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis

…, ES Gerasimov, J Gockley, BA Logsdon, DM Duong… - Nature …, 2021 - nature.com
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer’s
disease (AD) 1 , 2 , but how these loci confer AD risk is unclear. Here, we aimed to identify loci …