[HTML][HTML] Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation

D Ushizima, Y Chen, M Alegro, D Ovando, R Eser… - NeuroImage, 2022 - Elsevier
Abnormal tau inclusions are hallmarks of Alzheimer's disease and predictors of clinical decline.
Several tau PET tracers are available for neurodegenerative disease research, opening …

Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation

M Alegro, Y Chen, D Ovando, H Heinser, R Eser… - BioRxiv, 2019 - biorxiv.org
Deposits of abnormal tau protein inclusions in the brain are a pathological hallmark of
Alzheimer’s disease (AD), and are the best predictor of neuronal loss and clinical decline, but …

[PDF][PDF] Deep learning based large-scale histological tau protein mapping for neuroimaging biomarker validation in Alzheimer's disease

M Alegro, Y Chen, D Ovando, H Heinsen, R Eser… - bioRxiv, 2019 - academia.edu
Deposits of abnormal tau protein inclusions in the brain are one of the pathological hallmarks
of Alzheimer’s disease (AD) and are the best predictor of neuronal loss and clinical decline…

Caspase‐6‐mediated tau cleavage and pathology in Alzheimer's disease and other tauopathies: Developing topics

AMH Piergies, P Theofilas, C Petersen… - Alzheimer's & …, 2020 - Wiley Online Library
Background Caspases are being explored as targets for pharmacological treatment of
tauopathies due to their role in tau cleavage, which leads to tau aggregation and neuronal loss. …

Large scale, voxel‐to‐voxel correlation analysis of tau positron emission tomography signal to histological pathology in non‐Alzheimer tauopathies: Neuroimaging …

Y Chen, M Alegro, DO Morales, R Joie… - Alzheimer's & …, 2020 - Wiley Online Library
Background Tau pathology strongly correlates with neuronal loss and clinical decline across
tauopathies, emphasizing the need to detect and monitor tau pathology in living patients. …

A manual multiplex immunofluorescence method for investigating neurodegenerative diseases

AJ Ehrenberg, DO Morales, AMH Piergies, SH Li… - Journal of neuroscience …, 2020 - Elsevier
Background Neurodegenerative diseases feature stereotypical deposits of protein aggregates
that selectively accumulate in vulnerable cells. The ability to simultaneously localize …

Avaliação da esclerose hipocampal e de aspectos inflamatórios, apoptóticos e cognitivos em pacientes portadores de epilepsia do lobo temporal

EC de Brito Toscano - 2019 - repositorio.ufmg.br
… oportunidade de conviver com sua linda família; ao Joseph Oh e Dulce Ovando, pelo
aprendizado intensivo (I would like to say thank you to Joseph and Dulce for the intense learning). …

[PDF][PDF] Biodistribution and pharmacokinetics of AAVRh. 10-A1AT mediated gene therapy in humanized-liver mice as a predictor of A1AT human expression levels …

D Cepeda, B Belbellaa, E Yeh, A Rosario… - HUMAN GENE …, 2019 - adverum.com
Results Figure 1. Comparison of the serum concentration of A1AT in C57/B6J and PXB
mice following intravenous administration of 1x1011vg of different AAVRh. 10 vector capsid …

Multiplex immunofluorescence methods in neurodegenerative diseases

AJ Ehrenberg, DO Morales, JS Tejedor, J Mulder… - bioRxiv, 2019 - biorxiv.org
BACKGROUND The ability to simultaneously localize multiple targets within human tissue
sections would markedly facilitate the discovery and validation of molecular pathways …

Cambios relativos del nivel del mar en el Canal Beagle, Tierra del Fuego (Cenozoico Tardío), en base al análisis palinológico

MS Candel - 2010 - repositoriodigital.uns.edu.ar
… de agua dulce por escurrimiento superficial. En el área del Archipiélago Cormoranes (Río
Ovando, … , a un alto aporte de agua dulce por escorrentía superficial. La baja diversidad de las …