Autophagy, the major degradative pathway for organelles and long-lived proteins, is essential
for the survival of neurons. Mounting evidence has implicated defective autophagy in the …

Neuronal survival requires continuous lysosomal turnover of cellular constituents delivered
by autophagy and endocytosis. Primary lysosomal dysfunction in inherited congenital “…

Autophagy is implicated in the pathogenesis of major neurodegenerative disorders although
concepts about how it influences these diseases are still evolving. Once proposed to be …

Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis …

Nicastrin, a transmembrane glycoprotein, forms high molecular weight complexes with
presenilin 1 and presenilin 2. Suppression of nicastrin expression in Caenorhabditis elegans …

We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of
familial Alzheimer's disease mutations on amyloid β-peptide (Aβ) biogenesis. TgCRND8 mice …

Autophagy, a major degradative pathway for proteins and organelles, is essential for survival
of mature neurons. Extensive autophagic-lysosomal pathology in Alzheimer’s disease …

Small interfering RNA (siRNA) has become a powerful tool for selectively silencing gene
expression in cultured mammalian cells. Because different siRNAs of the same gene have …

Amyloid-β (Aβ) assembly into fibrillar structures is a defining characteristic of Alzheimer's
disease that is initiated by a conformational transition from random coil to β-sheet and a …

Background: RNA interference (RNAi) is a phenomenon in which introduced double-stranded
RNAs (dsRNAs) silence gene expression through specific degradation of their cognate …