User profiles for Duncan Palmer
 | Duncan PalmerPostdoctoral Research Fellow, Broad Institute, Massachusetts General Hospital Verified email at broadinstitute.org Cited by 9169 |
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
[PDF][PDF] Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
[PDF][PDF] Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
Genome-wide association studies have successfully discovered thousands of common
variants associated with human diseases and traits, but the landscape of rare variations in …
variants associated with human diseases and traits, but the landscape of rare variations in …
Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia
We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find …
sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find …
Autism spectrum disorder and attention deficit hyperactivity disorder have a similar burden of rare protein-truncating variants
…, M Bækvad-Hansen, DS Palmer… - Nature …, 2019 - nature.com
The exome sequences of approximately 8,000 children with autism spectrum disorder (ASD)
and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, …
and/or attention deficit hyperactivity disorder (ADHD) and 5,000 controls were analyzed, …
UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits
…, F Riveros-Mckay, C Giner-Delgado, D Palmer… - MedRxiv, 2022 - medrxiv.org
We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set
of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …
of PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …
Heterogeneous ground and air platforms, homogeneous sensing: Team CSIRO Data61's approach to the DARPA subterranean challenge
Heterogeneous teams of robots, leveraging a balance between autonomy and human
interaction, bring powerful capabilities to the problem of exploring dangerous, unstructured …
interaction, bring powerful capabilities to the problem of exploring dangerous, unstructured …
Common risk variants identified in autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants …