Adeno-associated viruses (AAVs) from clade E are often used as vectors in gene delivery
applications. This clade includes rhesus isolate 10 (AAVrh.10) and 39 (AAVrh.39) which, …

A computational method is described that allows the measurement of the signal-to-noise
ratio and resolution of a three-dimensional structure obtained by single particle electron …

Atomic structures of adeno-associated virus (AAV)-DJ, alone and in complex with fondaparinux,
have been determined by cryoelectron microscopy at 3 Å resolution. The gene therapy …

10.7554/eLife.23687.001 ArfA rescues ribosomes stalled on truncated mRNAs by recruiting
release factor RF2, which normally binds stop codons to catalyze peptide release. We report …

The spliceosome is a multimegadalton RNA-protein machine that removes noncoding
sequences from nascent pre-mRNAs. Recruitment of the spliceosome to splice sites and …

Bocaparvoviruses are emerging pathogens of the Parvoviridae family. Human bocavirus 1 (HBoV1)
causes severe respiratory infections and HBoV2 to HBoV4 cause gastrointestinal …

Tropomyosin (Tm) is a key factor in the molecular mechanisms that regulate the binding of
myosin motors to actin filaments (F-Actins) in most eukaryotic cells. This regulation is …

Adeno-associated virus (AAV) has emerged as a promising gene delivery vector because of
its non-pathogenicity, simple structure and genome, and low immunogenicity compared to …

The structural mechanics of tropomyosin are essential determinants of its affinity and positioning
on F-actin. Thus, tissue-specific differences among tropomyosin isoforms may influence …

The AAV2.7m8 vector is an engineered capsid with a 10-amino acid insertion in adeno-associated
virus (AAV) surface variable region VIII (VR-VIII) resulting in the alteration of an …