We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …

Polycomb group proteins are essential for early development in metazoans, but their
contributions to human development are not well understood. We have mapped the Polycomb …

The transcriptional regulatory networks that specify and maintain human tissue diversity are
largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation …

The design of small complexes that bind and react at specific sequences of DNA becomes
important as we begin to delineate, on a molecular level, how genetic information is …

Hormones and nutrients often induce genetic programs via signaling pathways that interface
with gene-specific activators. Activation of the cAMP pathway, for example, stimulates …

How species with similar repertoires of protein-coding genes differ so markedly at the phenotypic
level is poorly understood. By comparing organ transcriptomes from vertebrate species …

The NOTCH1 signaling pathway directly links extracellular signals with transcriptional
responses in the cell nucleus and plays a critical role during T cell development and in the …

Gorillas are humans’ closest living relatives after chimpanzees, and are of comparable
importance for the study of human origins and evolution. Here we present the assembly and …

Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To
explore the evolution of gene regulation, we used chromatin immunoprecipitation with high-…

The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals. …