User profiles for Duomeng Yang
 | DUOMENG YANGUconn Health Verified email at uchc.edu Cited by 426 |
[HTML][HTML] The development of COVID-19 treatment
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused
a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest …
a pandemic named coronavirus disease 2019 (COVID-19) that has become the greatest …
[HTML][HTML] Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction
Intrinsic cardiac adrenergic (ICA) cells regulate both developing and adult cardiac physiological
and pathological processes. However, the role of ICA cells in septic cardiomyopathy is …
and pathological processes. However, the role of ICA cells in septic cardiomyopathy is …
[HTML][HTML] Ulinastatin ameliorates pulmonary capillary endothelial permeability induced by sepsis through protection of tight junctions via inhibition of TNF-α and related …
M Fang, W Zhong, W Song, Y Deng, D Yang… - Frontiers in …, 2018 - frontiersin.org
Background: Increased permeability of pulmonary capillary is a common consequence of
sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor (…
sepsis that leads to acute lung injury. In this connection, ulinastatin, a urinary trypsin inhibitor (…
[HTML][HTML] Differential roles of RIG-I like receptors in SARS-CoV-2 infection
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5)
sense viral RNA and activate antiviral immune responses. Herein we investigate their …
sense viral RNA and activate antiviral immune responses. Herein we investigate their …
[HTML][HTML] β1-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation
Y Wang, Y Wang, D Yang, X Yu, H Li, X Lv, D Lu… - Critical care, 2015 - Springer
Introduction Caspase activation and cardiomyocyte apoptosis have been implicated in
lipopolysaccharide (LPS)-induced cardiac contractile dysfunction. We have recently …
lipopolysaccharide (LPS)-induced cardiac contractile dysfunction. We have recently …
Phenylephrine attenuated sepsis-induced cardiac inflammation and mitochondrial injury through an effect on the PI3K/Akt signaling pathway
H Li, K Li, Y Xing, X Tang, D Yang, X Dai… - Journal of …, 2019 - journals.lww.com
Objective: To investigate whether phenylephrine (PE) inhibits sepsis-induced cardiac dysfunction,
cardiac inflammation, and mitochondrial injury through the PI3K/Akt signaling pathway…
cardiac inflammation, and mitochondrial injury through the PI3K/Akt signaling pathway…
A critical role for STING signaling in limiting pathogenesis of Chikungunya virus
The stimulator of interferon gene (STING) pathway controls both DNA and RNA virus infection.
STING is essential for induction of innate immune responses during DNA virus infection, …
STING is essential for induction of innate immune responses during DNA virus infection, …
[HTML][HTML] UBR5 promotes antiviral immunity by disengaging the transcriptional brake on RIG-I like receptors
D Yang, T Geng, AG Harrison, JG Cahoon… - Nature …, 2024 - nature.com
The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral RNA
sensors essential for the initiation of antiviral immune responses. RLRs are subjected to …
sensors essential for the initiation of antiviral immune responses. RLRs are subjected to …
[HTML][HTML] α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation
X Yu, Y Wang, D Yang, X Tang, H Li, X Lv, R Qi, C Hu… - Scientific reports, 2018 - nature.com
Cardiomyopathy is a common complication associated with increased mortality in sepsis, but
lacks specific therapy. Here, using genetic and pharmacological approaches, we explored …
lacks specific therapy. Here, using genetic and pharmacological approaches, we explored …
Berberine in combination with yohimbine attenuates sepsis-induced neutrophil tissue infiltration and multiorgan dysfunction partly via IL-10-mediated inhibition of …
Y Wang, F Wang, D Yang, X Tang, H Li, X Lv… - International …, 2016 - Elsevier
Infiltration of activated neutrophils into the vital organs contributes to the multiple organ
dysfunctions in sepsis. In the present study, we investigated the effects of berberine in …
dysfunctions in sepsis. In the present study, we investigated the effects of berberine in …