User profiles for Durga Attili
 | Durga AttiliUniversity of Michigan Verified email at med.umich.edu Cited by 561 |
[PDF][PDF] Iron uptake via DMT1 integrates cell cycle with JAK-STAT3 signaling to promote colorectal tumorigenesis
Dietary iron intake and systemic iron balance are implicated in colorectal cancer (CRC)
development, but the means by which iron contributes to CRC are unclear. Gene expression and …
development, but the means by which iron contributes to CRC are unclear. Gene expression and …
Identification, isolation and characterization of human LGR5-positive colon adenoma cells
The intestine is maintained by stem cells located at the base of crypts and distinguished by
the expression of LGR5. Genetically engineered mouse models have provided a wealth of …
the expression of LGR5. Genetically engineered mouse models have provided a wealth of …
[HTML][HTML] A method for cryogenic preservation of human biopsy specimens and subsequent organoid culture
Results/Discussion Endoscopic biopsy specimens were collected with 8-mm2 biopsy forceps
(average biopsy size, 5 mm2), transported to the laboratory, divided further into 2-to 3-mm2 …
(average biopsy size, 5 mm2), transported to the laboratory, divided further into 2-to 3-mm2 …
Transferrin Receptor‐Mediated Iron Uptake Promotes Colon Tumorigenesis
Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive
iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, …
iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, …
[HTML][HTML] Human colonic crypts in culture: segregation of immunochemical markers in normal versus adenoma-derived
In order to advance a culture model of human colonic neoplasia, we developed methods for
the isolation and in vitro maintenance of intact colonic crypts from normal human colon …
the isolation and in vitro maintenance of intact colonic crypts from normal human colon …
[HTML][HTML] Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties
Background and aims Human colonoid cultures maintained under low-calcium (0.25 mM)
conditions undergo differentiation spontaneously and, concomitantly, express a high level of …
conditions undergo differentiation spontaneously and, concomitantly, express a high level of …
[HTML][HTML] Calcium-induced differentiation in normal human colonoid cultures: Cell-cell/cell-matrix adhesion, barrier formation and tissue integrity
Background and aims The goal of the study was to assess calcium alone and Aquamin, a
multi-mineral natural product that contains magnesium and detectable levels of 72 trace …
multi-mineral natural product that contains magnesium and detectable levels of 72 trace …
[HTML][HTML] Ulcerative colitis-derived colonoid culture: a multi-mineral-approach to improve barrier protein expression
Background Recent studies demonstrated that Aquamin ® , a calcium-, magnesium-rich,
multi-mineral natural product, improves barrier structure and function in colonoids obtained …
multi-mineral natural product, improves barrier structure and function in colonoids obtained …
Calcium-induced differentiation of human colon adenomas in colonoid culture: calcium alone versus calcium with additional trace elements
Previous murine studies have demonstrated that dietary Aquamin, a calcium-rich, multi-mineral
natural product, suppressed colon polyp formation and transition to invasive tumors more …
natural product, suppressed colon polyp formation and transition to invasive tumors more …
Monoclonal antibodies specific for oncofetal antigen–immature laminin receptor protein: effects on tumor growth and spread in two murine models
The oncofetal antigen – immature laminin receptor protein (OFA/iLRP) has been linked to
metastatic tumor spread for several years. The present study, in which 2 highly-specific, high-…
metastatic tumor spread for several years. The present study, in which 2 highly-specific, high-…