Identifying active site residues strictly from protein three-dimensional structure is a difficult
task, especially for proteins that have few or no homologues. We transformed protein …

Melanoma is one of the deadliest human cancers, responsible for approximately 80% of skin
cancer mortalities. The aggressiveness of melanoma is due to its capacity to proliferate and …

Background Breast cancer is a heterogeneous disease comprising several biologically
different types, exhibiting diverse responses to treatment. In the past years, gene expression …

One proposed strategy for bone regeneration involves ex vivo tissue engineering, accomplished
using bone-forming cells, biodegradable scaffolds, and dynamic culture systems, with …

Dysfunction of the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors
and vision loss and is correlated with common blinding disorders in humans. Although …

This work redefines the role of monocyte-derived dendritic cells in melanoma and provides
a novel strategy to increase the efficacy of T-cell–based immunotherapies in nonresponding …

Background Analysis of large genomic datasets along with their accompanying clinical
information has shown great promise in cancer research over the last decade. Such datasets …

Cutaneous melanoma tumors are heterogeneous and show diverse responses to treatment.
Identification of robust molecular biomarkers for classifying melanoma tumors into clinically …

We have analyzed gene expression data from three different kinds of samples: normal human
tissues, human cancer cell lines, and leukemic cells from lymphoid and myeloid leukemia …

Using DNA microarray and cluster analysis of expressed genes in a cloned line (M1-t-p53)
of myeloid leukemic cells, we have analyzed the expression of genes that are preferentially …