Background Vascularized composite allografts, particularly hand and forearm, have limited
ischemic tolerance after procurement. In bilateral hand transplantations, this demands a 2 …

We recently described myonectin (also known as erythroferrone) as a novel skeletal muscle–derived
myokine with metabolic functions. Here, we use a genetic mouse model to …

Specialized proresolving mediators (SPMs) actively limit inflammation and expedite its
resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular lipid …

Tendons play a critical role in the transmission of forces between muscles and bones, and
chronic tendon injuries and diseases are among the leading causes of musculoskeletal …

Central and peripheral mechanisms are both required for proper control of energy homeostasis.
Among circulating plasma proteins, C1q/TNF-related proteins (CTRPs) have recently …

Secreted proteins of the C1q/TNF-related protein (CTRP) family play diverse functions in
different organ systems. In the brain, CTRP14/C1QL1 is required for the proper establishment …

Obesity is a major risk factor for SARS-CoV-2 infection and COVID-19 severity. The underlying
basis of this association is likely complex in nature. The host-cell receptor angiotensin …

Tenocytes serve to synthesize and maintain collagen fibrils and other extracellular matrix
proteins in tendon. Despite the high prevalence of tendon injury, the underlying biologic …

Central obesity with cardiometabolic syndrome (CMS) is a major global contributor to
human disease, and effective therapies are needed. Here, we show that cyclic GMP–selective …

The platelet‐derived growth factor receptors alpha and beta ( PDGFR α and PDGFR β) mark
fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. …