CD4 expression and Env conformation are critical for HIV-1 restriction by SERINC5
X Zhang, J Shi, X Qiu, Q Chai, DA Frabutt… - Journal of …, 2019 - Am Soc Microbiol
Serine incorporator 5 (SERINC5) is a recently identified restriction factor that strongly blocks
HIV-1 entry but is counteracted by Nef. Notably, tier 1 HIV-1 Env proteins are sensitive to …
HIV-1 entry but is counteracted by Nef. Notably, tier 1 HIV-1 Env proteins are sensitive to …
Identification of SERINC5-001 as the predominant spliced isoform for HIV-1 restriction
…, J Yang, Y Lin, J Shi, X Zhang, DA Frabutt… - Journal of …, 2017 - Am Soc Microbiol
Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was
reported to strongly inhibit HIV-1 replication, which is counteracted by Nef. Ser5 produces 5 …
reported to strongly inhibit HIV-1 replication, which is counteracted by Nef. Ser5 produces 5 …
Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER …
DA Frabutt, B Wang, S Riaz, RC Schwartz… - Journal of …, 2018 - Am Soc Microbiol
Innate immunity provides an immediate defense against infection after host cells sense
danger signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of …
danger signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of …
[HTML][HTML] Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function
B Wang, Y Wang, DA Frabutt, X Zhang, X Yao… - Journal of Biological …, 2017 - ASBMB
The Ebola virus (EBOV) trimeric envelope glycoprotein (GP) precursors are cleaved into the
receptor-binding GP 1 and the fusion-mediating GP 2 subunits and incorporated into virions …
receptor-binding GP 1 and the fusion-mediating GP 2 subunits and incorporated into virions …
[HTML][HTML] Subgenomic particles in rAAV vectors result from DNA lesion/break and non-homologous end joining of vector genomes
J Zhang, P Guo, X Yu, DA Frabutt, AK Lam… - … Therapy-Nucleic Acids, 2022 - cell.com
Recombinant adeno-associated virus (rAAV) vectors have been developed for therapeutic
treatment of genetic diseases. Current rAAV vectors administered to affected individuals often …
treatment of genetic diseases. Current rAAV vectors administered to affected individuals often …
[HTML][HTML] Chemical modification of AAV9 capsid with N-ethyl maleimide alters vector tissue tropism
PL Mulcrone, AK Lam, D Frabutt, J Zhang… - Scientific Reports, 2023 - nature.com
Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue tropism
remains an unresolved challenge that limits its full potential despite that the tissue tropism …
remains an unresolved challenge that limits its full potential despite that the tissue tropism …
Multiple Reaction Monitoring Profiling (MRM-Profiling) of Lipids To Distinguish Strain-Level Differences in Microbial Resistance in Escherichia coli
…, CR Ferreira, A Vorsilak, D Frabutt… - Analytical …, 2019 - ACS Publications
The worldwide increase in antimicrobial resistance is due to antibiotic overuse in agriculture
and overprescription in medicine. For appropriate and timely patient support, faster …
and overprescription in medicine. For appropriate and timely patient support, faster …
[PDF][PDF] HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity
…, MK Collins, R Li, I Ahmad, SF Johnson, DA Frabutt… - Cell reports, 2021 - cell.com
HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting
this potent restriction factor to the endosomes and lysosomes for degradation. However, …
this potent restriction factor to the endosomes and lysosomes for degradation. However, …
[HTML][HTML] Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the
skyrocketing rate of AAV research and the prevalence of many new engineered capsids …
skyrocketing rate of AAV research and the prevalence of many new engineered capsids …
Chemical modifications of the capsid for redirecting and improving the efficacy of adeno-associated virus vectors
AK Lam, D Frabutt, L Li, W Xiao - Human gene therapy, 2021 - liebertpub.com
Adeno-associated virus (AAV) vector-directed gene therapy is one of the most exciting
modalities of biotechnology as more applications enter clinical stage. Although AAV vectors …
modalities of biotechnology as more applications enter clinical stage. Although AAV vectors …