User profiles for Dylan G. Ryan

Dylan Gerard Ryan

Research associate, University of Cambridge
Verified email at cam.ac.uk
Cited by 4557

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon… - Nature, 2018 - nature.com
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …

Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

A Hooftman, CG Peace, DG Ryan, EA Day, M Yang… - Nature, 2023 - nature.com
Metabolic rewiring underlies the effector functions of macrophages 1 , 2 – 3 , but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …

Coupling Krebs cycle metabolites to signalling in immunity and cancer

DG Ryan, MP Murphy, C Frezza, HA Prag… - Nature …, 2019 - nature.com
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists,
with exciting advances providing new insights into the mechanisms underlying disease…

Krebs cycle reborn in macrophage immunometabolism

DG Ryan, LAJ O'Neill - Annual review of immunology, 2020 - annualreviews.org
A striking change has happened in the field of immunology whereby specific metabolic
processes have been shown to be a critical determinant of immune cell activation. Multiple …

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

…, DG Ryan, SE Corcoran, G Timmons… - Proceedings of the …, 2018 - National Acad Sciences
A variety of innate immune responses and functions are dependent on time of day, and many
inflammatory conditions are associated with dysfunctional molecular clocks within immune …

[HTML][HTML] Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

…, R Goldbach-Mansky, M Motwani, DG Ryan… - Nature …, 2018 - nature.com
The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2
also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an …

[PDF][PDF] A defective pentose phosphate pathway reduces inflammatory macrophage responses during hypercholesterolemia

…, M van Weeghel, S van der Velden, DG Ryan… - Cell reports, 2018 - cell.com
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …

[PDF][PDF] Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

DG Ryan, EV Knatko, AM Casey, JL Hukelmann… - Iscience, 2022 - cell.com
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective
protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its …

[HTML][HTML] Caspase-11 promotes allergic airway inflammation

…, MM Hughes, C Diskin, K Banahan, DG Ryan… - Nature …, 2020 - nature.com
Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed
pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits caspase-11-dependent …

TCA cycle signalling and the evolution of eukaryotes

DG Ryan, C Frezza, LAJ O'Neill - Current opinion in biotechnology, 2021 - Elsevier
A major question remaining in the field of evolutionary biology is how prokaryotic organisms
made the leap to complex eukaryotic life. The prevailing theory depicts the origin of …