User profiles for Dylan G. Ryan
Dylan Gerard RyanResearch associate, University of Cambridge Verified email at cam.ac.uk Cited by 4557 |
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
The endogenous metabolite itaconate has recently emerged as a regulator of macrophage
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
function, but its precise mechanism of action remains poorly understood 1 , 2 , 3 . Here we …
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Metabolic rewiring underlies the effector functions of macrophages 1 , 2 – 3 , but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …
involved remain incompletely defined. Here, using unbiased metabolomics and stable …
Coupling Krebs cycle metabolites to signalling in immunity and cancer
Metabolic reprogramming has become a key focus for both immunologists and cancer biologists,
with exciting advances providing new insights into the mechanisms underlying disease…
with exciting advances providing new insights into the mechanisms underlying disease…
Krebs cycle reborn in macrophage immunometabolism
DG Ryan, LAJ O'Neill - Annual review of immunology, 2020 - annualreviews.org
A striking change has happened in the field of immunology whereby specific metabolic
processes have been shown to be a critical determinant of immune cell activation. Multiple …
processes have been shown to be a critical determinant of immune cell activation. Multiple …
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
…, DG Ryan, SE Corcoran, G Timmons… - Proceedings of the …, 2018 - National Acad Sciences
A variety of innate immune responses and functions are dependent on time of day, and many
inflammatory conditions are associated with dysfunctional molecular clocks within immune …
inflammatory conditions are associated with dysfunctional molecular clocks within immune …
[HTML][HTML] Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
The transcription factor Nrf2 is a critical regulator of inflammatory responses. If and how Nrf2
also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an …
also affects cytosolic nucleic acid sensing is currently unknown. Here we identify Nrf2 as an …
[PDF][PDF] A defective pentose phosphate pathway reduces inflammatory macrophage responses during hypercholesterolemia
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …
how systemic metabolism influences immune cell metabolism and function remains to be …
[PDF][PDF] Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
DG Ryan, EV Knatko, AM Casey, JL Hukelmann… - Iscience, 2022 - cell.com
To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective
protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its …
protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its …
[HTML][HTML] Caspase-11 promotes allergic airway inflammation
Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed
pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits caspase-11-dependent …
pyroptosis. Here we show that Prostaglandin E 2 (PGE 2 ) inhibits caspase-11-dependent …
TCA cycle signalling and the evolution of eukaryotes
A major question remaining in the field of evolutionary biology is how prokaryotic organisms
made the leap to complex eukaryotic life. The prevailing theory depicts the origin of …
made the leap to complex eukaryotic life. The prevailing theory depicts the origin of …