The epigenetic DNA modification 5-hydroxymethylcytosine (5hmC) has crucial roles in
development and gene regulation 1 , 2 , 3 , 4 , 5 , 6 , 7 . Quantifying the abundance of this …

Protein–DNA interactions are critical to the regulation of gene expression, but it remains
challenging to define how cell-to-cell heterogeneity in protein–DNA binding influences gene …

Genomic imprinting directs the allele-specific marking and expression of loci according to
their parental origin. Differential DNA methylation at imprinted control regions (ICRs) is …

Variability in gene expression contributes to phenotypic heterogeneity even in isogenic
populations. Here, we used the stereotyped, Wnt signaling-dependent development of the …

Organoid evolution models complemented with integrated single-cell sequencing technology
provide a powerful platform to characterize intra-tumor heterogeneity (ITH) and tumor …

Protein–DNA interactions are essential for establishing cell type–specific chromatin architecture
and gene expression. We recently developed scDam&T-seq, a multi-omics method that …

RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which
provide these proteins with a modular architecture. Accumulating evidence supports that …

DNA methylation (5mC) is central to cellular identity. The global erasure of 5mC from the
parental genomes during preimplantation mammalian development is critical to reset the …

We have developed a quantitative technique for sorting cells on the basis of endogenous
RNA abundance, with a molecular resolution of 10–20 transcripts. We demonstrate efficient …

Protein-DNA interactions are critical to the regulation of gene expression, but it remains
challenging to define how cell-to-cell heterogeneity in protein-DNA binding influences gene …