We discuss the fascinating pharmacology of formylpeptide receptor 2 (FPR2; often referred
to as FPR2/ALX since it binds lipoxin A 4 ). Initially identified as a low‐affinity ‘relative’ of …

The advancement of microRNA (miRNA) therapies has been hampered by difficulties in
delivering miRNA to the injured kidney in a robust and sustainable manner. Using …

… (72) Using the same benzo-LXA 4 analogue, Brennan and colleagues also demonstrated
that LXs protects against diabetes-associated complications, including accelerated …

Biological scaffolds composed of extracellular matrix (ECM) have been shown to be resistant
to deliberate bacterial contamination in preclinical in vivo studies. The present study …

Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes
and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or …

Lipoxins, which are endogenously produced lipid mediators, promote the resolution of
inflammation, and may inhibit fibrosis, suggesting a possible role in modulating renal disease. …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk remain …

Biological scaffolds composed of naturally occurring extracellular matrix (ECM) have been
utilized as templates for the constructive remodelling of numerous tissues in preclinical …

<p>We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to
examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 …

Transforming growth factor-beta (TGF-β1) is implicated in the onset and progression of
renal fibrosis and diabetic nephropathy (DN), leading to a loss of epithelial characteristics of …