In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular
accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. …

Cholesterol can be detrimental or vital, and must be present in the right place at the right]time
and in the right amount. This is well known in the heart and the vascular system.However, …

Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex
glycosphingolipids play very important roles in cell function under physiological conditions …

The goal of this study was to assess the relative importance of the axonal synthesis of
phosphatidylcholine for neurite growth using rat sympathetic neurons maintained in …

Nerve fiber elongation involves the input of lipids to the growing axons. Since cell bodies
are often a great distance from the regenerating tips, alternative sources of lipids have been …

Extracellular accumulation of β-amyloid peptide (Aβ) has been linked to the development of
Alzheimer disease. The importance of intraneuronal Aβ has been recognized more recently. …

Injured peripheral but not central nerves regenerate their axons but functional recovery is
often poor. We demonstrate that prolonged periods of axon separation from targets and …

Glia modulate neuronal activity by releasing transmitters in a process called gliotransmission.
The role of this process in controlling the activity of neuronal networks underlying motor …

At least 50% of the major axonal membrane lipid, phosphatidylcholine, of rat sympathetic
neurons is synthesized in situ in axons [Posse de Chaves, Vance, Campenot and Vance (1995…

Lipoproteins originating from axon and myelin breakdown in injured peripheral nerves are
believed to supply cholesterol to regenerating axons. We have used compartmented cultures …