A host of observations demonstrating the relationship between nuclear architecture and
processes such as gene expression have led to a number of new technologies for interrogating …

The presence of maternal and paternal homologs appears to be much more than just a
doubling of genetic material. We know this because genomes have evolved elaborate …

Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying
nuclear structure and organization. Here we report two advances in FISH-based imaging. We …

Widespread changes to DNA methylation and chromatin are well documented in cancer,
but the fate of higher-order chromosomal structure remains obscure. Here we integrated …

… during interphase can be maintained independent of cohesin or with reduced amounts of
cohesin, possibly due to redundancy with pairing interactions between homologs (Joyce, EF, …

Higher-order chromatin structure regulates gene expression, and mutations in proteins
mediating genome folding underlie developmental disorders known as cohesinopathies. …

… This work was supported by fellowships from the Busch foundation to EF Joyce, the National
Science Foundation to KS McKim, and the Natural Sciences and Engineering Research …

Background Association of chromatin with lamin proteins at the nuclear periphery has emerged
as a potential mechanism to coordinate cell type-specific gene expression and maintain …

Topologically Associating Domains (TADs) separate vertebrate genomes into insulated
regulatory neighborhoods that focus genome-associated processes. TADs are formed by …

The human genome can be segmented into topologically associating domains (TADs),
which have been proposed to spatially sequester genes and regulatory elements through …