User profiles for E. G. Atkinson

Elizabeth G. Atkinson

Baylor College of Medicine
Verified email at bcm.edu
Cited by 3683

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

…, W Zhang, M Adams, I Agartz, EG Atkinson… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

[HTML][HTML] International meta-analysis of PTSD genome-wide association studies identifies sex-and ancestry-specific genetic risk loci

…, AX Maihofer, T Klengel, EG Atkinson… - Nature …, 2019 - nature.com
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD …

The emerging role of osteocytes in cancer in bone

EG Atkinson, J Delgado‐Calle - JBMR plus, 2019 - Wiley Online Library
Advances in the last decade have established the osteocyte, the most abundant cell in bone,
as a dynamic and multifunctional cell capable of controlling bone homeostasis by …

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

EG Atkinson, AX Maihofer, M Kanai, AR Martin… - Nature …, 2021 - nature.com
Admixed populations are routinely excluded from genomic studies due to concerns over
population structure. Here, we present a statistical framework and software package, Tractor, to …

Strategies for the genomic analysis of admixed populations

T Tan, EG Atkinson - Annual review of biomedical data science, 2023 - annualreviews.org
… Cross-continental human populations thus typically have larger (eg, African and European
populations have ), whereas within-continental populations have smaller (eg, Finnish and …

[PDF][PDF] An unexpectedly complex architecture for skin pigmentation in Africans

…, JM Granka, JW Myrick, X Liu, A Sockell, EG Atkinson… - Cell, 2017 - cell.com
… Because haplotype differentiation between populations can be a signature of selection (eg,
XP-EHH scans), we assessed genetic divergence between KhoeSan, West African, and …

A weakly structured stem for human origins in Africa

AP Ragsdale, TD Weaver, EG Atkinson, EG Hoal… - Nature, 2023 - nature.com
Despite broad agreement that Homo sapiens originated in Africa, considerable uncertainty
surrounds specific models of divergence and migration across the continent 1 . Progress is …

Cross-ancestry genomic research: time to close the gap

EG Atkinson, SB Bianchi, GY Ye… - …, 2022 - nature.com
… outreach and education efforts (eg, workshops, community … that only require summary statistics
(eg, Multi-Ancestry Meta-… localize signals closer to causal variants (eg [14]). In addition to …

Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

HM Davis, R Pacheco‐Costa, EG Atkinson, LR Brun… - Aging cell, 2017 - Wiley Online Library
Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the
generation/function of bone forming and resorbing cells. Aging also decreases connexin43 (…

[PDF][PDF] No evidence for recent selection at FOXP2 among diverse human populations

EG Atkinson, AJ Audesse, JA Palacios, DM Bobo… - Cell, 2018 - cell.com
FOXP2, initially identified for its role in human speech, contains two nonsynonymous substitutions
derived in the human lineage. Evidence for a recent selective sweep in Homo sapiens…