Neurofibromin is a cytoplasmic protein that is predominantly expressed in neurons, Schwann
cells, oligodendrocytes, astrocytes and leukocytes. It is encoded by the gene NF1, located …

Over the past years, it has become evident that cancer initiation and progression depends
on several components of the tumor microenvironment, including inflammatory and immune …

We report a method for studying global DNA methylation based on using bisulfite treatment
of DNA and simultaneous PCR of multiple DNA repetitive elements, such as Alu elements …

Background Alterations in DNA methylation in cancer include global hypomethylation and
gene-specific hypermethylation. It is not clear whether these two epigenetic errors are …

Epithelial tissues are specialized to protect underlying tissues from environmental influences
such as physical and chemical agents, infection by invasive microorganisms as well as …

We conducted a genome-wide association study of oral cavity and pharyngeal cancer in
6,034 cases and 6,585 controls from Europe, North America and South America. We detected …

Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC),
although strongly divergent results have been reported regarding the prevalence of HPV16 in …

Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease affecting
the epithelium of the oral cavity, pharynx and larynx. Conditions of most patients are …

Background The role of human papillomavirus (HPV) on head and neck squamous cell
carcinoma (HNSCC) survival in regions with low HPV prevalence is not yet clear. We evaluated …

Background Current evidence implicates aberrant microRNA expression patterns in human
malignancies; measurement of microRNA expression may have diagnostic and prognostic …