User profiles for E. J. Villablanca
 | eduardo J villablancaKarolinska Institutet Verified email at ki.se Cited by 6447 |
Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance
B Cassani, EJ Villablanca, J De Calisto, S Wang… - Molecular aspects of …, 2012 - Elsevier
The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune
responses. RA is produced by gut-associated dendritic cells (DC) and is required for …
responses. RA is produced by gut-associated dendritic cells (DC) and is required for …
Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?
EJ Villablanca, K Selin, CRH Hedin - Nature Reviews Gastroenterology …, 2022 - nature.com
Almost all currently available treatments for inflammatory bowel disease (IBD) act by
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …
Mechanisms of pediatric inflammatory bowel disease
Inflammatory bowel disease (IBD), including Crohn disease and ulcerative colitis, is characterized
by chronic intestinal inflammation due to a complex interaction of genetic determinants…
by chronic intestinal inflammation due to a complex interaction of genetic determinants…
[HTML][HTML] Gut immune maturation depends on colonization with a host-specific microbiota
…, SM Edelman, EB Troy, NC Reading, EJ Villablanca… - Cell, 2012 - cell.com
Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We
colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to …
colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to …
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense
…, JM Peloquin, EJ Villablanca… - Proceedings of the …, 2014 - National Acad Sciences
A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like
1 (ATG16L1), confers increased risk for the development of Crohn disease, although the …
1 (ATG16L1), confers increased risk for the development of Crohn disease, although the …
Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
EJ Villablanca, L Raccosta, D Zhou, R Fontana… - Nature medicine, 2010 - nature.com
Sterol metabolism has recently been linked to innate and adaptive immune responses
through liver X receptor (LXR) signaling. Whether products of sterol metabolism interfere with …
through liver X receptor (LXR) signaling. Whether products of sterol metabolism interfere with …
[HTML][HTML] Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH
Methods to spatially profile the transcriptome are dominated by a trade-off between resolution
and throughput. Here we develop a method named Enhanced ELectric Fluorescence in …
and throughput. Here we develop a method named Enhanced ELectric Fluorescence in …
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection
…, HB Jijon, M Zhang, LN Aldrich, EJ Villablanca… - Gastroenterology, 2013 - Elsevier
Background & Aims Intestinal epithelial cells aid in mucosal defense by providing a physical
barrier against entry of pathogenic bacteria and secreting antimicrobial peptides (AMPs). …
barrier against entry of pathogenic bacteria and secreting antimicrobial peptides (AMPs). …
Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice
BACKGROUND & AIMS: Induction of oral immune tolerance (OT) blocks proinflammatory
responses to orally administered antigens and might be used to treat autoimmune conditions. …
responses to orally administered antigens and might be used to treat autoimmune conditions. …
[PDF][PDF] Distinct developmental pathways from blood monocytes generate human lung macrophage diversity
…, J Botling, MCI Karlsson, EJ Villablanca… - Immunity, 2021 - cell.com
The study of human macrophages and their ontogeny is an important unresolved issue.
Here, we use a humanized mouse model expressing human cytokines to dissect the …
Here, we use a humanized mouse model expressing human cytokines to dissect the …