It has been clear for a number of years that small DNA tumor viruses such as simian virus 40
(SV40) and papillomavirus interact with cell cycle control pathways during lytic replication in …

An expression vector was modified to permit the rapid synthesis of purified, UP-labeled,
glutathione S-transferase (GST)-retinoblastoma (RB) fusion proteins. The products were used to …

Previous studies have shown that the carboxyl-terminal region of E2F-1 (residues 368-437)
can support transcriptional activation when linked to the DNA-binding domain of the yeast …

The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is a functional
homologue of the tumor necrosis factor receptor family and contributes substantially to the …

… Flemington, unpublished data). To begin to address this issue, we first treated two type I
latency cell lines and an EBV-negative cell line with 5-aza-C, to induce type III latency gene …

Regulation of gene expression in mammals through methylation of cytosine residues at CpG
dinucleotides is involved in the development and progression of tumors. Because many …

We observed that microRNAs (miRNAs) that regulate differentiation in a variety of simpler
systems also regulate differentiation of human multipotent stromal cells (hMSCs) from bone …

The E2F family of transcription factors plays a key role in regulating cell-cycle progression.
Accordingly, E2F is itself tightly controlled by a series of transcriptional and posttranscriptional …

Constitutively active androgen receptor splice variants (AR-V) lacking the ligand-binding
domain have been implicated in the pathogenesis of castration-resistant prostate cancer and in …

Epstein-Barr virus (EBV) is associated with roughly 10% of gastric carcinomas worldwide (EBVaGC).
Although previous investigations provide a strong link between EBV and gastric …