User profiles for E. L. Bao
Erik L BaoHarvard Medical School Verified email at hms.harvard.edu Cited by 2202 |
Inherited causes of clonal haematopoiesis in 97,691 whole genomes
Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …
[PDF][PDF] The polygenic and monogenic basis of blood traits and diseases
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …
[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …
The genetics of human hematopoiesis and its disruption in disease
Hematopoiesis, or the process of blood cell production, is a paradigm of multi‐lineage
cellular differentiation that has been extensively studied, yet in many aspects remains …
cellular differentiation that has been extensively studied, yet in many aspects remains …
Interrogation of human hematopoiesis at single-cell and single-variant resolution
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation
represent substantial challenges to elucidating mechanisms of trait-associated genetic …
represent substantial challenges to elucidating mechanisms of trait-associated genetic …
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …
SLICE: determining cell differentiation and lineage based on single cell entropy
A complex organ contains a variety of cell types, each with its own distinct lineage and
function. Understanding the lineage and differentiation state of each cell is fundamentally …
function. Understanding the lineage and differentiation state of each cell is fundamentally …
[PDF][PDF] Transcriptional states and chromatin accessibility underlying human erythropoiesis
Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This
process is also of considerable interest for better understanding anemias and identifying new …
process is also of considerable interest for better understanding anemias and identifying new …
[HTML][HTML] A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology
Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …
immunity and thrombosis. Quantitative variation in these structures has not been subjected …
[HTML][HTML] Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications
of sickle cell disease (SCD), including stroke. However, little information exists on the …
of sickle cell disease (SCD), including stroke. However, little information exists on the …