User profiles for E. L. Bao

Erik L Bao

Harvard Medical School
Verified email at hms.harvard.edu
Cited by 2202

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

…, JS Weinstock, SK Nandakumar, CP Fulco, EL Bao… - Nature, 2020 - nature.com
Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

[PDF][PDF] The polygenic and monogenic basis of blood traits and diseases

D Vuckovic, EL Bao, P Akbari, CA Lareau, A Mousas… - Cell, 2020 - cell.com
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

…, B Trivedi, T Jiang, P Akbari, D Vuckovic, EL Bao… - Cell, 2020 - cell.com
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

The genetics of human hematopoiesis and its disruption in disease

EL Bao, AN Cheng, VG Sankaran - EMBO molecular medicine, 2019 - embopress.org
Hematopoiesis, or the process of blood cell production, is a paradigm of multi‐lineage
cellular differentiation that has been extensively studied, yet in many aspects remains …

Interrogation of human hematopoiesis at single-cell and single-variant resolution

JC Ulirsch, CA Lareau, EL Bao, LS Ludwig, MH Guo… - Nature …, 2019 - nature.com
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation
represent substantial challenges to elucidating mechanisms of trait-associated genetic …

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

EL Bao, SK Nandakumar, X Liao, AG Bick… - Nature, 2020 - nature.com
Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

SLICE: determining cell differentiation and lineage based on single cell entropy

M Guo, EL Bao, M Wagner, JA Whitsett… - Nucleic acids …, 2017 - academic.oup.com
A complex organ contains a variety of cell types, each with its own distinct lineage and
function. Understanding the lineage and differentiation state of each cell is fundamentally …

[PDF][PDF] Transcriptional states and chromatin accessibility underlying human erythropoiesis

LS Ludwig, CA Lareau, EL Bao, SK Nandakumar… - Cell reports, 2019 - cell.com
Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This
process is also of considerable interest for better understanding anemias and identifying new …

[HTML][HTML] A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology

…, T Jiang, K Kundu, R Kreuzhuber, EL Bao… - Nature …, 2023 - nature.com
Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …

[HTML][HTML] Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease

…, D Jain, HM Kang, N Pankratz, PL Auer, EL Bao… - PLoS …, 2018 - journals.plos.org
Co-inheritance of α-thalassemia has a significant protective effect on the severity of complications
of sickle cell disease (SCD), including stroke. However, little information exists on the …