All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization …

To dissect the genetic architecture of blood pressure and assess effects on target organ
damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 …

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide 1 , 2
. Although 58 genomic regions have been associated with CAD thus far 3 , 4 , 5 , 6 , 7 , 8 , 9 , …

Background Chronic low-grade inflammation reflects a subclinical immune response
implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA …

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

DNA methylation age is an accurate biomarker of chronological age and predicts lifespan,
but its underlying molecular mechanisms are unknown. In this genome-wide association …

Background Whole-exome sequencing (WES) has become an efficient diagnostic test for
patients with likely monogenic conditions such as rare idiopathic diseases or sudden …

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity,
our understanding of its functional relevance remains limited. Here we show the effect of …

Background Polygenic risk scores (PRSs) are a summarization of an individual’s genetic
risk for a disease or trait. These scores are being generated in research and commercial …

There are numerous hallmarks of aging in mammals, but no unifying cause has been identified.
In budding yeast, aging is associated with a loss of epigenetic information that occurs in …