Bone marrow fibrosis (BMF) develops in various hematological and non-hematological
conditions and is a central pathological feature of myelofibrosis. Effective cell-targeted …

The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a
major role in shaping the human genome, and this methylation damage remains the primary …

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) that leads to progressive
bone marrow (BM) fibrosis. Although the cellular mutations involved in the pathogenesis …

Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic
infection and cancer. Current in vivo models of CTL exhaustion using chronic viral infections or …

We show a novel paradigm in which chromosomal aberrations reveal critical regulatory
elements that are nonfunctional at their endogenous locus. This knowledge provides a rationale …

The murine embryonic–trophoblast–extra-embryonic endoderm (ETX) model is an integrated
stem cell–based model to study early postimplantation development. It is based on the self-…

MIR139 is a tumor suppressor and is commonly silenced in acute myeloid leukemia (AML).
However, the tumor-suppressing activities of miR-139 and molecular mechanisms of MIR139-…

Tumor-promoting inflammation is considered an enabling characteristic of tumorigenesis,
but mechanisms remain incompletely understood. By deciphering the predicted signaling …

… Identification of co-operating leukemia genes in the Em-TCL1 transgenic mouse with a
Sleeping Beauty transposon- mediated mutagenesis screen revealed increased nuclear factor (…

… Photomicrographs from paraffin sections of embryonic chick heart fragments confronted
in organ culture with the cell lines T24 (A) and 1207 (B) that invaded the fragments and two …