… We thank members of the De La Cruz and Ostap laboratories for helpful discussions, and
Lee Ligon and Chris Yengo for comments on the manuscript. EDLC is supported by grants …

… 1c; De La Cruz 2005). Efficient filament severing is readily … and promote fragmentation (De
La Cruz 2005). Mathematical … or a few bound cofilin molecules (De La Cruz 2005; see also …

RNA helicase enzymes catalyze the in vivo folding and conformational re-arrangement of
RNA. DEAD-box proteins (DBPs) make up the largest family of RNA helicases and are found …

… Weak-binding myosin states dynamically detach and rebind to actin with a low affinity (K d
> 1 μM), whereas the strong-binding myosin states remain bound to actin with a … De La Cruz …

… (D) The radius and total fluorescence intensities of both actin and myosin were recorded for
all angular sectors over time. (E) Ring constriction kinetics. Time series of length … De La Cruz …

… De La Cruz and TD Pollard, submitted for publication). The final sucrose concentration is
calculated to be 51% (w/v). In control samples, the 5 min preincubation with EGTA was omitted, …

Myosin V is a double-headed processive molecular motor that moves along an actin
filament by taking 36-nm steps. Using optical trapping nanometry with high spatiotemporal …

Diseases of ectopic calcification of the vascular wall range from lethal orphan diseases
such as generalized arterial calcification of infancy (GACI), to common diseases such as …

The assembly of actin monomers into filaments and networks plays vital roles throughout
eukaryotic biology, including intracellular transport, cell motility, cell division, determining …

We investigate, using molecular dynamics, how the severing protein, actin depolymerization
factor (ADF)/cofilin, modulates the structure, conformational dynamics, and mechanical …