The building of population pharmacokinetic/pharmacodynamic (PK/PD) models is a time
consuming and complicated task. This is partly due the lack of specialized tools for the …

The NONMEM program is the most widely used nonlinear regression software in population
pharmacokinetic/pharmacodynamic (PK/PD) analyses. In this article we describe a …

Purpose. One important task in population pharmacokinetic/pharmacodynamic model
building is to identify the relationships between the parameters and demographic factors (…

The objectives of this study were to assess the difference between actual and nominal
significance levels, as judged by the likelihood ratio test, for hypothesis tests regarding covariate …

The aim of this study was to compare 2 stepwise covariate model-building strategies,
frequently used in the analysis of pharmacokinetic-pharmacodynamic (PK-PD) data using …

The aim of this study was to characterize the relationship between warfarin concentrations
and international normalized ratio (INR) response and to identify predictors important for dose …

Deriving a population pharmacokinetic model from real data is always associated with
numerous assumptions. Violations of these assumptions, especially if undetected, may lead to …

The objective of this study was to compare the blood-brain barrier (BBB) transport and brain
distribution of levo- (R-CZE) and dextrocetirizine (S-CZE). Microdialysis probes, calibrated …

We propose a model that characterizes and links the complexity and diversity of clinically
observed hepatitis C viral kinetics to sustained virologic response (SVR)—the primary clinical …

The objective of the study was to update a previous NONMEM model to describe the relationship
between warfarin dose and international normalized ratio (INR) response, to decrease …