HIV-1 Nef: a master manipulator of the membrane trafficking machinery mediating immune evasion
EN Pawlak, JD Dikeakos - Biochimica et Biophysica Acta (BBA)-General …, 2015 - Elsevier
Background Many viral genomes encode a limited number of proteins, illustrating their innate
efficiency in bypassing host immune surveillance. This concept of genomic efficiency is …
efficiency in bypassing host immune surveillance. This concept of genomic efficiency is …
[HTML][HTML] HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling
BS Dirk, EN Pawlak, AL Johnson, LR Van Nynatten… - Scientific reports, 2016 - nature.com
A defining characteristic of HIV-1 infection is the ability of the virus to persist within the host.
Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical …
Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical …
[HTML][HTML] Efferocytic defects in early atherosclerosis are driven by GATA2 overexpression in macrophages
…, M Rosoga, J Akingbasote, EN Pawlak… - Frontiers in …, 2020 - frontiersin.org
… Pawlak Emily N. Pawlak 1 Rajesh Abraham Jacob Rajesh Abraham Jacob 1 Jonathan Hu
Jonathan Hu 1 Neha Sharma Neha Sharma 1 Jimmy D. Dikeakos Jimmy D. Dikeakos 1 Lillian …
Jonathan Hu 1 Neha Sharma Neha Sharma 1 Jimmy D. Dikeakos Jimmy D. Dikeakos 1 Lillian …
Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2
…, EY Liu, J Ellins, AM Vrieze, EN Pawlak… - European Journal of …, 2019 - Wiley Online Library
Efferocytosis is essential for homeostasis and prevention of the inflammatory and autoimmune
diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein …
diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein …
[HTML][HTML] The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells
Background The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple
host proteins to modify the immune response and increase viral persistence. Nef and Vpu can …
host proteins to modify the immune response and increase viral persistence. Nef and Vpu can …
[HTML][HTML] The interaction between HIV-1 Nef and adaptor protein-2 reduces Nef-mediated CD4+ T cell apoptosis
Acquired Immune Deficiency Syndrome is characterized by a decline in CD4 + T cells. Here,
we elucidated the mechanism underlying apoptosis in Human Immunodeficiency Virus-1 (…
we elucidated the mechanism underlying apoptosis in Human Immunodeficiency Virus-1 (…
[HTML][HTML] Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways
The Human Immunodeficiency Virus type 1 (HIV-1) accessory protein Nef interacts with a
multitude of cellular proteins, manipulating the host membrane trafficking machinery to evade …
multitude of cellular proteins, manipulating the host membrane trafficking machinery to evade …
PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway
BS Dirk, C End, EN Pawlak, LR Van Nynatten… - Biochemical and …, 2018 - Elsevier
The regulated secretory pathway is a specialized form of protein secretion found in endocrine
and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that …
and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that …
Microwave transitions in atomic sodium: Radiometry and polarimetry using the sodium layer
M Pawlak, EL Schoen, JE Albert, HR Sadeghpour - Physical Review A, 2024 - APS
We calculate, via variational techniques, single-and two-photon Rydberg microwave transitions,
as well as scalar and tensor polarizabilities of the sodium atom using the parametric one…
as well as scalar and tensor polarizabilities of the sodium atom using the parametric one…
[HTML][HTML] Identification of Novel Subcellular Localization and Trafficking of HIV-1 Nef Variants from Reference Strains G (F1. 93. HH8793) and H (BE. 93. VI997)
LR Van Nynatten, AL Johnson, BS Dirk, EN Pawlak… - Viruses, 2018 - mdpi.com
The human immunodeficiency virus type 1 (HIV-1) accessory protein Nef, plays an essential
role in disease progression and pathogenesis via hijacking the host cellular membrane-…
role in disease progression and pathogenesis via hijacking the host cellular membrane-…