Recent advances have led to a more detailed understanding of RNA interference and its role
in microRNA biogenesis and function. Primary microRNA transcripts are processed by the …

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a
transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is …

Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT)
are the only known naturally occurring clonally transmissible cancers. These cancers are …

To address the biological function of RNA interference (RNAi)-related pathways in mammals,
we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, …

Pseudogenes populate the mammalian genome as remnants of artefactual incorporation of
coding messenger RNAs into transposon pathways 1 . Here we show that a subset of …

Dicer is an RNase III-family nuclease that initiates RNA interference (RNAi) and related
phenomena by generation of the small RNAs that determine the specificity of these gene …

Cardiovascular disease is the leading cause of human morbidity and mortality. Dilated
cardiomyopathy (DCM) is the most common form of cardiomyopathy associated with heart failure. …

The mammalian radiation has corresponded with rapid changes in noncoding regions of the
genome, but we lack a comprehensive understanding of regulatory evolution in mammals. …

Dicer is an essential component of RNA interference (RNAi) pathways, which have broad
functions in gene regulation and genome organization. Probing the consequences of tissue-…

The discovery that microRNAs (miRNAs) play important roles in regulating gene expression
via posttranscriptional repression has revealed a previously unsuspected mechanism …