Oxygen is a molecule that is central to cellular respiration and viability, yet there are multiple
physiologic and pathological contexts in which cells experience conditions of insufficient …

Despite the fact that a surgical procedure may have been performed for the appropriate
indication and in a technically perfect manner, patients are threatened by perioperative organ …

Immunological memory provides the basis for successful vaccines. It is important to understand
the properties of memory cells. There is much known about the phenotype and functions …

Recent studies have demonstrated dramatic shifts in metabolic supply-and-demand ratios
during inflammation, a process resulting in localized tissue hypoxia within inflammatory …

Intercellular transfer of microRNAs can mediate communication between critical effector
cells. We hypothesized that transfer of neutrophil-derived microRNAs to pulmonary epithelial …

Five-year survival for human papilloma virus-unrelated head and neck squamous cell
carcinomas remain below 50%. We assessed the safety of administering combination …

Immune checkpoint inhibitors targeting the interaction between programmed cell death-1 (PD-1)
and its ligand PD-L1 induce tumor regression in a subset of non–small cell lung cancer …

Mass cytometry has revolutionized the study of cellular and phenotypic diversity, significantly
expanding the number of phenotypic and functional characteristics that can be measured at …

The incidence of cancer is higher in the elderly; however, many of the underlying mechanisms
for this association remain unexplored. Here, we have shown that B cell progenitors in old …

… These findings build upon two elegant studies by Kratky et al. and Sporri et al. that
demonstrated the need for direct TLR ligation on antigen-presenting cells to elicit T-cell immunity, …