[PDF][PDF] The human gut virome is highly diverse, stable, and individual specific

…, KM Daly, JA Nolan, SA McDonnell, EV Khokhlova… - Cell host & …, 2019 - cell.com
The human gut contains a vast array of viruses, mostly bacteriophages. The majority remain
uncharacterized, and their roles in shaping the gut microbiome and in impacting on human …

[HTML][HTML] Features of DNA repair in the early stages of mammalian embryonic development

EV Khokhlova, ZS Fesenko, JV Sopova, EI Leonova - Genes, 2020 - mdpi.com
Cell repair machinery is responsible for protecting the genome from endogenous and
exogenous effects that induce DNA damage. Mutations that occur in somatic cells lead to …

[HTML][HTML] ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis

AN Shkoporov, EV Khokhlova, CB Fitzgerald… - Nature …, 2018 - nature.com
CrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to
infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and …

[HTML][HTML] Structural atlas of a human gut crassvirus

…, EV Khokhlova, JLR Smith, DEDP Hawkins, EV Koonin… - Nature, 2023 - nature.com
EV Khokhlova and CH were supported by Science Foundation Ireland (SFI) under Grant
no. SFI/12/RC/2273. NY and EV Koonin are supported by the Intramural Research Program of …

Viral biogeography of the mammalian gut and parenchymal organs

…, C Heuston, A Upadrasta, EV Khokhlova… - Nature …, 2022 - nature.com
The mammalian virome has been linked to health and disease but our understanding of how
it is structured along the longitudinal axis of the mammalian gastrointestinal tract (GIT) and …

[HTML][HTML] Isolation and characterisation of ΦcrAss002, a crAss-like phage from the human gut that infects Bacteroides xylanisolvens

…, SR Stockdale, JC Comas, EV Khokhlova… - Microbiome, 2021 - Springer
Background The gut phageome comprises a complex phage community of thousands of
individual strains, with a few highly abundant bacteriophages. CrAss-like phages, which infect …

Anti‐inflammatory properties of intestinal Bifidobacterium strains isolated from healthy infants

EV Khokhlova, VV Smeianov, BA Efimov… - Microbiology and …, 2012 - Wiley Online Library
Certain Bifidobacterium strains have been shown to inhibit inflammatory responses in
intestinal epithelial cells. However, the precise mechanisms of these effects, including the …

[HTML][HTML] Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis

AN Shkoporov, EV Khokhlova, N Stephens, C Hueston… - BMC biology, 2021 - Springer
Background The crAss-like phages are ubiquitous and highly abundant members of the human
gut virome that infect commensal bacteria of the order Bacteroidales. Although incapable …

[HTML][HTML] Probing the “Dark Matter” of the human gut phageome: culture assisted metagenomics enables rapid discovery and host-linking for novel bacteriophages

…, AN Shkoporov, A Upadrasta, EV Khokhlova… - Frontiers in cellular …, 2021 - frontiersin.org
Recent years have been marked by the growing interest towards virulent and temperate
bacteriophage populations inhabiting the human lower gastrointestinal tract – the gut phageome…

Alistipes inops sp. nov. and Coprobacter secundus sp. nov., isolated from human faeces

…, AV Chaplin, EV Khokhlova… - … of systematic and …, 2015 - microbiologyresearch.org
Culture-based study of the faecal microbiome in two adult female subjects revealed the
presence of two obligately anaerobic, non-spore-forming, rod-shaped, non-motile, Gram-…