Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations
D Miroshnychenko, E Baratchart… - Nature Ecology & …, 2021 - nature.com
The initiation and progression of cancers reflect the underlying process of somatic evolution,
in which the diversification of heritable phenotypes provides a substrate for natural selection…
in which the diversification of heritable phenotypes provides a substrate for natural selection…
[HTML][HTML] Hybrid Automata Library: A flexible platform for hybrid modeling with real-time visualization
RR Bravo, E Baratchart, J West… - PLoS computational …, 2020 - journals.plos.org
… Modelers can click on regions within these bars to change regions to a new treatment intensity
selected in (E). Modelers may also use the hotkeys presented in (E) to apply the selected …
selected in (E). Modelers may also use the hotkeys presented in (E) to apply the selected …
[HTML][HTML] Computational modelling of metastasis development in renal cell carcinoma
E Baratchart, S Benzekry, A Bikfalvi… - PLoS computational …, 2015 - journals.plos.org
The biology of the metastatic colonization process remains a poorly understood phenomenon.
To improve our knowledge of its dynamics, we conducted a modelling study based on …
To improve our knowledge of its dynamics, we conducted a modelling study based on …
[HTML][HTML] Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing
… e Temporal plots and corresponding goodness of fit metrics (AIC and R2s) across all
populations, … e temporal plots and corresponding goodness of fit metrics (AIC and R2s) across all …
populations, … e temporal plots and corresponding goodness of fit metrics (AIC and R2s) across all …
[HTML][HTML] Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair
Bone-forming osteoblasts and -resorbing osteoclasts control bone injury repair, and myeloid-derived
cells such as monocytes and macrophages are known to influence their behavior. …
cells such as monocytes and macrophages are known to influence their behavior. …
[HTML][HTML] Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
…, A Bukkuri, N Engström, E Baratchart… - Cancer research …, 2024 - AACR
In response to cisplatin treatment, some surviving cancer cells undergo whole-genome
duplications without mitosis, which represents a mechanism of drug resistance. This study …
duplications without mitosis, which represents a mechanism of drug resistance. This study …
[HTML][HTML] From Ecology to Cancer Biology and Back Again
Application of evolutionary concepts to the study of cancer progression transformed cancer
research in the 1970's (Cairns, 1975; Nowell, 1976) and inspired novel approaches to …
research in the 1970's (Cairns, 1975; Nowell, 1976) and inspired novel approaches to …
Hybrid Automata Library: A modular platform for efficient hybrid modeling with real-time visualization
… Modelers can click on regions within these bars to change regions to a new treatment intensity
selected in (E). Modelers may also use the hotkeys presented in (E) to apply the selected …
selected in (E). Modelers may also use the hotkeys presented in (E) to apply the selected …
[HTML][HTML] Origin and evolution of animal multicellularity in the light of phylogenomics and cancer genetics
F Jacques, E Baratchart, KJ Pienta, EU Hammarlund - Medical Oncology, 2022 - Springer
The rise of animals represents a major but enigmatic event in the evolutionary history of life.
In recent years, numerous studies have aimed at understanding the genetic basis of this …
In recent years, numerous studies have aimed at understanding the genetic basis of this …
Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair
Bone-forming osteoblasts and -resorbing osteoclasts control bone injury repair, and myeloid-derived
cells such as monocytes and macrophages are known to influence their behavior. …
cells such as monocytes and macrophages are known to influence their behavior. …