Tau-targeting therapies for Alzheimer disease

EE Congdon, EM Sigurdsson - Nature Reviews Neurology, 2018 - nature.com
Alzheimer disease (AD) is the most common form of dementia. Pathologically, AD is
characterized by amyloid plaques and neurofibrillary tangles in the brain, with associated loss of …

A neurogenetic approach to impulsivity

E Congdon, T Canli - Journal of personality, 2008 - Wiley Online Library
Impulsivity is a complex and multidimensional trait that is of interest to both personality
psychologists and to clinicians. For investigators seeking the biological basis of personality traits, …

[HTML][HTML] Pathways of tau fibrillization

J Kuret, CN Chirita, EE Congdon… - … et Biophysica Acta (BBA …, 2005 - Elsevier
New methods for analyzing tau fibrillization have yielded insights into the biochemical
transitions involved in the process. Here we review the parallels between the sequential …

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

…, O Chiba-Falek, A Christoforou, ET Cirulli, E Congdon… - Nature …, 2018 - nature.com
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

…, TD Cannon, ET Cirulli, E Congdon… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Methods for in vitro percutaneous absorption studies II. Animal models for human skin

RL Bronaugh, RF Stewart, ER Congdon - Toxicology and applied …, 1982 - Elsevier
The percutaneous absorption of compounds through the skin of selected animal species
was compared to that occurring with human skin, using in vitro diffusion cell techniques. The …

[HTML][HTML] Transformation of the aortic arch system during the development of the human embryo

ED Congdon - Contrib Embryol, 1922 - books.google.com
… 17, e). The rapid approximation of the vessels and their final meeting can not be explained
by the slowing ingrowth of the wall between them. As in the movement of the innominate and …

[HTML][HTML] GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

…, E London, RA Poldrack, FW Sabb, E Congdon… - Molecular …, 2017 - nature.com
The complex nature of human cognition has resulted in cognitive genomics lagging behind
many other fields in terms of gene discovery using genome-wide association study (GWAS) …

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

EE Congdon, JW Wu, N Myeku, YH Figueroa… - Autophagy, 2012 - Taylor & Francis
More than 30 neurodegenerative diseases including Alzheimer disease (AD), frontotemporal
lobe dementia (FTD), and some forms of Parkinson disease (PD) are characterized by the …

Neural correlates of epigenesis

T Canli, M Qiu, K Omura, E Congdon… - Proceedings of the …, 2006 - National Acad Sciences
The effect of life stress on depression is moderated by a repeat length variation in the
transcriptional control region of the serotonin transporter gene, which renders carriers of the short …