The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent
fascinating models for deciphering the light input pathway to the vertebrate clock since fish …

Daily light and feeding cycles act as powerful synchronizers of circadian rhythmicity. Ultimately,
these external cues entrain the expression of clock genes, which generate daily rhythmic …

Objective— Diurnal variations in levels of factor VII (FVII), FVIII, proteins C and S, antithrombin,
plasminogen activator inhibitor-1, prothrombin fragment F 1+2 , and D-dimers in healthy …

… Positive elements such as CLOCK and BMAL bind to E-box elements located in the regulatory
regions of negative elements (pers and crys). CRY and PER proteins down-regulate their …

Brain-derived neurotrophic factor (BDNF) plays a pivotal role in neuronal growth and
differentiation, neuronal plasticity, learning, and memory. Using CRISPR/Cas9 technology, we …

The genetic basis of phenotypic changes in extreme environments is a key but rather
unexplored topic in animal evolution. Here we provide an exemplar case of evolution by relaxed …

… These proteins bind as heterodimeric complexes to canonical E-box enhancer elements (5′-CACGTG-3′)
present in the promoter regions of the negative elements of the circuit (the …

… proximity to their transcription start sites, and canonical E-box elements (50-CACGTG-30)
(Figure 6G and Table S3). While the E-boxes potentially represent binding sites for the core …

Glucocorticoids (GCs) are steroid hormones mainly acting as key regulators of body
homeostasis and stress responses. Their activities are primarily based on the binding to the GC …

… Briefly, a positive loop includes CLOCK-BMAL heterodimers, transcriptional activators
that bind to E-box elements located in the promoter of negative elements such as Period (Pers), …