Capacity of oxidative phosphorylation in human skeletal muscle: new perspectives of mitochondrial physiology

E Gnaiger - The international journal of biochemistry & cell biology, 2009 - Elsevier
… Coupling control from OXPHOS to ETS capacity, J O 2 , P to J O 2 , E , is evaluated by
uncoupler titration (CI + II E ). Inhibition of CI by rotenone shows substrate control from CI + II …

Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply

E Gnaiger - Respiration physiology, 2001 - Elsevier
Oxygen limitation is generally considered as impairment of mitochondrial respiration under
hypoxia and ischemia. Low intracellular oxygen levels under normoxia, however, imply mild …

Control of mitochondrial and cellular respiration by oxygen

E Gnaiger, R Steinlechner-Maran, G Méndez… - Journal of bioenergetics …, 1995 - Springer
… This formalism for a coupled process remains valid for serial uncoupling (Gnaiger, 1993c),
when proton ttanslocation has actually taken place and energy is dissipated owing to serially …

Calculation of energetic and biochemical equivalents of respiratory oxygen consumption

E Gnaiger - … oxygen sensors: aquatic and physiological applications, 1983 - Springer
The evaluation of metabolic energy loss is the major aim of respiratory studies in ecological
energetics and for the construction of energy budgets. The polarographic oxygen sensor is …

High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle

D Pesta, E Gnaiger - Mitochondrial bioenergetics: methods and protocols, 2012 - Springer
… Inhibition of E by oligomycin should be evaluated by uncoupler titrations in the absence of …
The phosphorylation system control ratio, P/E increases from a minimum of L/E if the capacity …

[HTML][HTML] Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle

R Boushel, E Gnaiger, P Schjerling, M Skovbro… - Diabetologia, 2007 - Springer
Aims/hypothesis Insulin resistance and type 2 diabetes are associated with mitochondrial
dysfunction. The aim of the present study was to test the hypothesis that oxidative …

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

…, N Scharf, A Althaym, R Clara, M Roden, E Gnaiger… - Diabetes, 2004 - Am Diabetes Assoc
Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic effects via
different mechanisms. As evidence suggests that both impair cell respiration in vitro, this study …

Proximate biochemical composition and caloric content calculated from elemental CHN analysis: a stoichiometric concept

E Gnaiger, G Bitterlich - Oecologia, 1984 - Springer
… (4)), and WE e values are backcalculated to w L fractions in real samples by multiplication
… Draw a vertical line from Wc e to get the intercept with the line paralleling KL. The horizontal …

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

…, F Gorus, J Buyse, F Sluse, RA Harris, E Gnaiger… - Nature …, 2008 - nature.com
HIF prolyl hydroxylases (PHD1–3) are oxygen sensors that regulate the stability of the
hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of …

Mitochondrial Oxygen Affinity, Respiratory Flux Control And Excess Capacity Of Cytochrome c Oxidase

E Gnaiger, B Lassnig, A Kuznetsov… - Journal of …, 1998 - journals.biologists.com
… of the oxygen-dependence varies among species and may be complex, yet a surprisingly
simple hyperbolic equation describes the flux/pressure relationship in some cases (Gnaiger, …