Whether the brain tumor medulloblastoma originates from stem cells or restricted progenitor
cells is unclear. To investigate this, we activated oncogenic Hedgehog (Hh) signaling in …

Recent studies have identified stem cells in brain cancer. However, their relationship to
normal CNS progenitors, including dependence on common lineage-restricted pathways, is …

MicroRNAs (miRNAs) carry out post-transcriptional control of a multitude of cellular processes.
Aberrant expression of miRNA can lead to diseases, including cancer. Gliomas are …

… (E) Quantitation of percentage of viable cells after radiation treatment as compared with …
(E) Immunohistochemistry of tumors derived from injections of p53 mutant BT70 human glioma …

Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option
is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, yet it
remains refractory to systemic therapy. Elimination of senescent cells has emerged as a …

Down-regulated bymos (Drm)/Gremlin is a highly conserved protein whose properties and
expression pattern suggest a role in early development, tissue-specific differentiation, and cell …

Glioblastoma (GBM), a uniformly lethal brain cancer, is characterized by diffuse invasion
and abnormal activation of multiple receptor tyrosine kinase (RTK) signaling pathways, …

Although malignant astrocytomas are a leading cause of cancer-related death in children,
rational therapeutic strategies are lacking. We previously identified activating mutations of v-…

… redundant functions, we next chose to neutralise all of them by overexpressing the E protein
E47. Since Id proteins have been shown to strongly bind E proteins, we reasoned that an …