Patients with established type 2 diabetes display both β-cell dysfunction and insulin
resistance. To define fundamental processes leading to the diabetic state, we examined the …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

… Corresponding authors of these studies (n = 19) were contacted by electronic and regular
mail (two electronic reminders) and invited to submit data using a standardized data extraction …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background— Vitamin D receptors have a broad tissue distribution that includes vascular
smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that …

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D),
we conducted a meta-analysis of genetic variants on the Metabochip, including …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels. …