User profiles for E. John Wherry
E. John WherryUniversity of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 103068 |
Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or inflammatory
signals. This scenario is often associated with the deterioration of T cell function: a state …
signals. This scenario is often associated with the deterioration of T cell function: a state …
[PDF][PDF] Molecular signature of CD8+ T cell exhaustion during chronic viral infection
Chronic viral infections often result in T cell exhaustion. To determine the molecular signature
of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic …
of exhaustion, we compared the gene-expression profiles of dysfunctional lymphocytic …
Defining 'T cell exhaustion'
…, AH Sharpe, DE Speiser, EJ Wherry… - Nature Reviews …, 2019 - nature.com
… E. John Wherry. I agree that T cell exhaustion is an evolutionarily conserved adaptation
to chronic antigen stimulation that is probably important to limit immunopathology or …
to chronic antigen stimulation that is probably important to limit immunopathology or …
[HTML][HTML] T cell responses in patients with COVID-19
Z Chen, E John Wherry - Nature Reviews Immunology, 2020 - nature.com
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to
provide long-term protection from reinfection with SARS-CoV-2, remains debated. …
provide long-term protection from reinfection with SARS-CoV-2, remains debated. …
[HTML][HTML] Lineage relationship and protective immunity of memory CD8 T cell subsets
EJ Wherry, V Teichgräber, TC Becker, D Masopust… - Nature …, 2003 - nature.com
Memory CD8 T cells can be divided into two subsets, central (T CM ) and effector (T EM ), but
their lineage relationships and their ability to persist and confer protective immunity are not …
their lineage relationships and their ability to persist and confer protective immunity are not …
Restoring function in exhausted CD8 T cells during chronic viral infection
Functional impairment of antigen-specific T cells is a defining characteristic of many chronic
infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To …
infections, but the underlying mechanisms of T-cell dysfunction are not well understood. To …
T cell exhaustion
EJ Wherry - Nature immunology, 2011 - nature.com
… E John Wherry … & Wherry, EJ CD8 T cell dysfunction during chronic viral infection. Curr.
Opin. … Shin, H., Blackburn, SD, Blattman, JN & Wherry, EJ Viral antigen and extensive division …
Opin. … Shin, H., Blackburn, SD, Blattman, JN & Wherry, EJ Viral antigen and extensive division …
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with severe …
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
…, B Zhu, Q Eichbaum, M Altfeld, EJ Wherry… - Nature, 2006 - nature.com
Functional impairment of T cells is characteristic of many chronic mouse and human viral
infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a …
infections. The inhibitory receptor programmed death 1 (PD-1; also known as PDCD1), a …
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
INTRODUCTION Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA
vaccines are highly effective at preventing infection and especially severe disease. However, …
vaccines are highly effective at preventing infection and especially severe disease. However, …