Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide …

Background Both genetic variation at the 17q21 locus and virus-induced respiratory wheezing
illnesses are associated with the development of asthma. Our aim was to determine the …

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …

Background Preterm birth, low birth weight, and infant catch-up growth seem associated
with an increased risk of respiratory diseases in later life, but individual studies showed …

Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood 1 . Previous genome-…

A large number of genetic loci are associated with adult body mass index. However, the
genetics of childhood body mass index are largely unknown. We performed a meta-analysis of …

Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in
the pathogenesis of allergic disease. We performed the first large-scale genome-wide …

Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both
the central onset of puberty and local growth factors. Although little is known about the …

Rationale: An asthma predisposition locus on chromosome 17q12-q21 has recently been
replicated in different ethnic groups. Objectives: To characterize the asthma and atopy …