Induced pluripotent stem (iPS) cells can be obtained from fibroblasts upon expression of
Oct4, Sox2, Klf4, and c-Myc. To understand how these factors induce pluripotency, we carried …

Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable and …

We combined Gal4-UAS and the FLP recombinase–FRT and fluorescent reporters to
generate cell clones that provide spatial, temporal and genetic information about the origins of …

The healthcare sector generates approximately 10% of the total carbon emissions in the United
States. Radiology is thought to be a top contributor to the healthcare carbon footprint due …

Generating induced pluripotent stem cells (iPSCs) requires massive epigenome reorganization.
It is unclear whether reprogramming of female human cells reactivates the inactive X …

… We review early detection biomarkers, explore the potential of using social media for detection,
appraise prediction models developed using electronic health records and research data…

BACKGROUND AND PURPOSE: Convolutional neural networks are a powerful technology
for image recognition. This study evaluates a convolutional neural network optimized for the …

Naive human embryonic stem cells (hESCs) can be derived from primed hESCs or directly
from blastocysts, but their X chromosome state has remained unresolved. Here, we show that …

Recent studies using the ratio of plasma aldosterone concentration (PAC) to PRA as the
screening test for primary aldosteronism in hypertensive populations suggested that the …

To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines
of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient …