The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …

… (eg) PLISH and immunostaining in human adult lung alveoli for (e) ACE2 (white), TMPRSS2
(green) and CTSL (red), (f) ACE2 (white), TMPRSS2 (green) and HTII-280 (red), (g) ACE2 (…

… e, Cell type capture is affected by protocol and location. Cell type proportion analysis with
fold changes and LTSR score for all cell type groups with regard to the material, protocol and …

Background The Human Cell Atlas is a large international collaborative effort to map all cell
types of the human body. Single-cell RNA sequencing can generate high-quality data for the …

… (E) Schematics of somatic mutation analysis and pairwise comparison from 60× WGS
data. (F) Pairwise comparison of BE versus NE and BE versus NG in two BE patients; their …

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy
human body at single-cell resolution to increase our understanding of basic biological …

… -stalk to late-airway progenitor to club cells (Figure S5E), although the oldest tip and stalk
cells included in this analysis may produce alveolar lineages (Figures S5E’, 3C, 3E, S6A, and …