Background The molecular cause of inflammatory bowel disease is largely unknown. Methods
We performed genetic-linkage analysis and candidate-gene sequencing on samples from …

Almost all protein database search methods use amino acid substitution matrices for scoring,
optimizing, and assessing the statistical significance of sequence alignments. Much care …

Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently
not well understood. Most affected individuals are simplex cases, but both autosomal-…

Background TBLASTN is a mode of operation for BLAST that aligns protein sequences to a
nucleotide database translated in all six frames. We present the first description of the …

The DUST module has been used within BLAST for many years to mask low-complexity
sequences. In this paper, we present a new implementation of the DUST module that uses the …

The object-oriented software package OOQP for solving convex quadratic programming
problems (QP) is described. The primal-dual interior point algorithms supplied by OOQP are …

BACKGROUND: The hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized
by infections of the lung and skin, elevated serum IgE, and involvement of the soft and …

We describe a novel clinical phenotype associating T- and B-cell lymphopenia, intermittent
neutropenia, and atrial septal defects in 3 members of a consanguineous kindred. Their …

TNFRSF13B encodes transmembrane activator and calcium modulator and cyclophilin
ligand interactor (TACI), a B cell– specific tumor necrosis factor (TNF) receptor superfamily …

Motivation: Matches to repetitive sequences are usually undesirable in the output of DNA
database searches. Repetitive sequences need not be matched to a query, if they can be …