Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in …

… & Olson, EN Signal-dependent nuclear export of a histone deacetylase regulates muscle
differentiation. Nature 408, 106–111 (2000). The first study to show that class IIa HDACs are …

▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …

Certain fish and amphibians retain a robust capacity for cardiac regeneration throughout life,
but the same is not true of the adult mammalian heart. Whether the capacity for cardiac …

The biochemical basis for the regulation of fibre-type determination in skeletal muscle is not
well understood. In addition to the expression of particular myofibrillar proteins, type I (slow-…

In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic
response characterized by increased myocardial cell size and activation of fetal cardiac genes. …

Acute myocardial infarction (MI) due to coronary artery occlusion is accompanied by a
pathological remodeling response that includes hypertrophic cardiac growth and fibrosis, which …

The heart responds to diverse forms of stress by hypertrophic growth accompanied by
fibrosis and eventual diminution of contractility, which results from down-regulation of α–myosin …

Endothelial cells play essential roles in maintenance of vascular integrity, angiogenesis, and
wound repair. We show that an endothelial cell-restricted microRNA (miR-126) mediates …

Diverse forms of injury and stress evoke a hypertrophic growth response in adult cardiac
myocytes, which is characterized by an increase in cell size, enhanced protein synthesis, …