We present a modular approach for analyzing calcium imaging recordings of large neuronal
ensembles. Our goal is to simultaneously identify the locations of the neurons, demix …

Calcium imaging is a popular tool among neuroscientists because of its capability to
monitor in vivo large neural populations across weeks with single neuron and single spike …

… c, e: Quantification of performance using the ROF measure averaged over space (c,
value in pixels) and over time (e, mean over time value of ROF in pixels). Consistently, pw-rigid …

10.7554/eLife.28728.001 In vivo calcium imaging through microendoscopic lenses enables
imaging of previously inaccessible neuronal populations deep within the brains of freely …

… We tested the CNMF-E implementation of CAIMAN BATCH on in vivo microendosopic data
from mouse dorsal striatum, with neurons expressing GCaMP6f. 6000 frames were acquired …

We developed a new way to engineer complex proteins toward multidimensional
specifications using a simple, yet scalable, directed evolution strategy. By robotically picking …

… We examine the DS of these cells in more detail in Figure 6E, and it is clear that we can
fully separate the functional activity of even strongly overlapping cells, without cross-…

… (e) Coronal cerebellar sections of the mouse shown in d, counterstained for GABA A α6.
Arrows point to a parallel fiber expressing GCaMP6f. (f) Fluorescent traces from parallel fiber …

The zebra finch brain features a set of clearly defined and hierarchically arranged motor
nuclei that are selectively responsible for producing singing behavior. One of these regions, a …

Inhibitory neurons, which play a critical role in decision-making models, are often simplified
as a single pool of non-selective neurons lacking connection specificity. This assumption is …