Background: The inability to efficiently repair DNA damage or remove cells with severely
damaged genomes has been linked to several human cancers. Studies in yeasts and mammals …

The goal of this work was to develop recombinantly expressed variable domains derived
from camelid heavy-chain antibodies known as single-domain antibodies (sdAbs) directed …

Mismatch repair genes are important in maintaining the fidelity of DNA replication. To
determine the function of the Caenorhabditis elegans homologue of the MSH2 mismatch repair …

c-Abl, a conserved nonreceptor tyrosine kinase, integrates genotoxic stress responses, acting
as a transducer of both pro- and antiapoptotic effector pathways 1 . Nuclear c-Abl seems to …

Synthesis of ribosomal RNA by RNA polymerase I (RNA pol I) is an elemental biological
process and is key for cellular homeostasis. In a forward genetic screen in C. elegans designed …

Lateral flow immunoassays (LFIs) are simple, point-of-care diagnostic devices used for
detecting biological agents or other analytes of interest in a sample. LFIs are predominantly …

Phages are natural predators of bacteria and have been exploited in bacterial detection
because of their exquisite specificity to their cognate bacterial hosts. In this study, we present a “…

The use of chemically or thermally inactivated biothreat toxins in detection methodologies
can prove problematic when the resulting toxoids become attenuated or altered to the point …

INFORMATION TO USERS Page 1 INFORMATION TO USERS This manuscript has been
reproduced from the microfilm master. UMI films the text directly from the original or copy …

There is no published data regarding whether human uterine tissues and leiomyomas contain
binding sites for epidermal growth factor (EGF). The present study was undertaken with 33 …