Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …

… values are calculated, it becomes apparent that Drugs A and B have a significantly higher
efficiency with 15- to 20-fold higher biophase concentrations with respect to Drugs C, D and E. …

ABSTRACT. Microalbuminuria is defined as abnormal urinary excretion of albumin between
30 and 300 mg/d. It can be measured accurately by several widely available and sensitive …

AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in
excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma …

BACKGROUND: Interferon (IFN)-alpha is an innate immune cytokine that causes high rates
of depression in humans and therefore has been used to study the impact of cytokines on …

Narcolepsy type 1 (NT1) is a sleep disorder caused by a loss of orexinergic neurons. Narcolepsy
type 2 (NT2) is heterogeneous; affected individuals typically have normal orexin levels. …

Background The identification of people at risk of cognitive impairment is essential for improving
recruitment in secondary prevention trials of Alzheimer's disease. We aimed to test and …

Objectives: To compare quantitative EEG signal and test-retest reliability of medical grade and
consumer EEG systems. Methods: Resting state EEG was acquired by two medical grade (…

… e The BB radius in km is the square root of this BB normalization, times the distance in
units of 10 kpc. * See Section 3.1 for details on the modeling of these observations. … The …

One of the major biological targets of free radical oxidations, prone, for anatomical reasons,
to oxidative challenges, is the cardiovascular system. In the present paper the effect of …