We present a consolidated view of the complexity and challenges of designing studies for
measurement of energy metabolism in mouse models, including a practical guide to the …

Calorie restriction (CR) extends life span and retards age-related chronic diseases in a
variety of species, including rats, mice, fish, flies, worms, and yeast. The mechanism or …

It is widely accepted that increasing adiposity is associated with insulin resistance and increased
risk of type 2 diabetes. The predominant paradigm used to explain this link is the portal/…

Leptin, the gene product of the obese gene, may play an important role in regulating body
weight by signalling the size of the adipose tissue mass. Plasma leptin was found to be highly …

The emergence of chronic inflammation during obesity in the absence of overt infection or
well-defined autoimmune processes is a puzzling phenomenon. The Nod-like receptor (NLR) …

Background The relative roles of obesity, insulin resistance, insulin secretory dysfunction, and
excess hepatic glucose production in the development of non-insulin-dependent diabetes …

Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue
receptor that has recently been isolated from the rat stomach. Ghrelin administration stimulates …

Daily human energy requirements calculated from separate components of energy
expenditure are inaccurate and usually in poor agreement with measured energy intakes. …

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these
effects are due solely to weight loss. We conducted the first supervised controlled feeding …

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a
critical variable in human health and physiology, but its trajectory over the life course is poorly …