The trichothecenes are a group of naturally-occurring sesquiterpenoid epoxides which
show a broad range of biological activity. They are powerful inhibitors of eukaryotic protein …

BACKGROUND: This is a progress report of the Alzheimer's Disease Neuroimaging Initiative
(ADNI) positron emission tomography (PET) Core. METHODS: The Core has supervised …

… Kaplan-Meier curves representing survival to symptom onset are shown in figure e-1. For
all mutation carriers, median survival to symptom onset was 47 years (95% confidence interval …

A modified procedure for purification of the adenosine 3',5'-monophosphate-dependent (cyclic
AMP-dependent) protein kinase from rabbit skeletal muscle is described. This procedure …

The glc7 mutant of the yeast Saccharomyces cerevisiae does not accumulate glycogen due
to a defect in glycogen synthase activation (Peng, Z., Trumbly, RJ, and Reimann, EM (1990) …

… FDG-PET) or functional magnetic resonance imaging (fMRI), with a dashed line to indicate
that synaptic dysfunction may be detectable in carriers of the ɛ4 allele of the apolipoprotein E …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Publisher Summary Most tissues contain protein kinases that are stimulated several-fold by
cyclic 3', 5'-adenosine monophosphate (cAMP) and catalyze the transfer of phosphate from …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

… The E4 variant of apolipoprotein E (APOE4), the main susceptibility gene for Alzheimer’s
disease 11 , 12 , 13 – 14 , leads to accelerated breakdown of the BBB and degeneration of …