Introduction. Paracetamol (acetaminophen) is one of the most common agents deliberately
ingested in self-poisoning episodes and a leading cause of acute liver failure in the western …

Chronic kidney disease affects millions of people worldwide and is associated with an
increased morbidity and mortality as a result of kidney failure and cardiovascular disease. …

Endosomal trafficking is an essential cellular process involved in the transport of proteins
such as integrins, hormone receptors, growth factor receptors, receptor tyrosine kinases, and …

We have used a c-Src-GFP fusion protein to address the spatial control of Src activation and
the nature of Src-associated intracellular structures during stimulus-induced transit to the …

… The research team gathered outcome and survival data via the electronic system at every
hospital and clinical notes, and they recorded this information in the case report form. We also …

Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK
pathway is severely perturbed. Depletion of FAK, detachment of FAK-proficient cells or …

Aims In S eptember 2012 the UK 's Commission on Human Medicines ( CHM ) recommended
changes in the management of paracetamol poisoning: use of a single ‘100 mg l −1 ’ …

… was abolished in FAK-Y397F-expressing cells (Figure 1E). We confirmed specificity of the
IP by use of nonimmune IgG (Figure 1E, right panel). Thus, FAK promotes nascent adhesion …

The non‐receptor tyrosine kinase Src is recruited to activated fibroblast growth factor receptor
(FGFR) complexes through the adaptor protein factor receptor substrate 2 (FRS2). Here, …

… There is impaired cell-cell adhesion in skin keratinocytes with dysregulation of E-cadherin,
hyperproliferation of differentiated cells, and ultimately apoptosis. Mechanistically, the primary …