… (E) We show two domains between 147.5 Mb and 149 Mb on chromosome 6 that are conserved
between GM12878 and IMR90. In GM12878, both domains are marked with H3K27me3 …

… , as in the case of the mutant lacking both E/Forward and E/Reverse. In this case, an
exclusion domain will not form between D and E because there is no EF loop to interfere with the …

… a–e include both FlowFISH data from this study and tested pairs from other studies. See …
of the E–G pair to the Hi-C signal at the bin of this row corresponding to the midpoint of E. …

… At the same time, particularly at CTCF sites adjacent to multiple loading sites, mutant cohesin
complexes colocalized with CTCF anchors (Figure 1E), indicating that their mobility is not …

During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and
adopts an unusual 3D configuration known as the “Barr body.” Despite the importance of X …

… Musial, Ragib Mostofa, Melanie Pham, Brian Glenn St Hilaire, Weijie Yao, Elena Stamenova,
Marie Hoeger, Sarah K. Nyquist, Valeriya Korchina, Kelcie Pletch, Joseph P. Flanagan, …

… e, Box plots displaying the RPKM of FOXA2 enrichment in BJ FOXA2 and BJ FOXA2–GATA4
at GATA4 stabilized sites compared with nonenriched sites. 318 of these 504 regions …

Mammalian cells stably maintain high levels of DNA methylation despite expressing both
positive (DNMT3A/B) and negative (TET1-3) regulators. Here, we analyzed the independent …

… e Mean methylation for all CpGs within six 40 kb target regions that are covered in three
independent clones over the Dox time course. Error bars display standard deviation for the three …

Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic
leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. …