Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

… Snail repression of E-cadherin. ERα with its corepressors NCoR and SAFB1 can bind to
and repress transcription of the E-cadherin promoter (201). Thus E-cadherin expression is …

Nuclear receptors (NRs) comprise a family of ligand inducible transcription factors. To
achieve transcriptional activation of target genes, DNA-bound NRs directly recruit general …

Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

… Indeed, we found that GPS2 is equally required for SUMO-dependent LXR transrepression
in human macrophages (N Venteclef and E Treuter, unpubl.). As these pathways connect …

In contrast with the class A heat stress transcription factors (HSFs) of plants, a considerable
number of HSFs assigned to classes B and C have no evident function as transcription …

… Whole-body knockout mice lacking RXRα show impaired myocardial growth and die
between embryonic day (E)13.5 and E16.5 . However, specific RXRα depletion in ventricular …

… In view of the results with the proline mutants (group E), we hypothesized that the proline
residue immediately adjacent to the FWEKFL motif of AHA2 might be responsible for the low …

The activation function 2/ligand-dependent interaction between nuclear receptors and their
coregulators is mediated by a short consensus motif, the so-called nuclear receptor (NR) box…

… E, Quantification of the amount of in vitro translated SHP proteins retained by the LXR-GST
column. The intensities of the specific bands were quantitated using a PhosphorImager (…