User profiles for E. Wamhoff

Eike-Christian Wamhoff

BioNTech SE
Verified email at biontech.de
Cited by 1105

Functionalizing DNA origami to investigate and interact with biological systems

GA Knappe, EC Wamhoff, M Bathe - Nature Reviews Materials, 2023 - nature.com
DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex biophysical …

Programming structured DNA assemblies to probe biophysical processes

EC Wamhoff, JL Banal, WP Bricker… - Annual review of …, 2019 - annualreviews.org
electronic and vibrational states on energy-transfer efficiency remains a point of debate.
Electronic coherence occurs when electronic states … In contrast, electronic-vibrational coherence …

[HTML][HTML] Role of nanoscale antigen organization on B-cell activation probed using DNA origami

R Veneziano, TJ Moyer, MB Stone, EC Wamhoff… - Nature …, 2020 - nature.com
Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like
nanoparticles to enhance B-cell activation. However, the effects of antigen copy number, …

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa

…, K Rox, A Varrot, D Hauck, EC Wamhoff… - Journal of the …, 2018 - ACS Publications
The opportunistic Gram-negative bacterium Pseudomonas aeruginosa is a leading pathogen
for infections of immuno-compromised patients and those suffering from cystic fibrosis. Its …

A specific, glycomimetic langerin ligand for human langerhans cell targeting

EC Wamhoff, J Schulze, L Bellmann… - ACS central …, 2019 - ACS Publications
… (e) 16 was docked into the carbohydrate binding site to rationalize the observations from 15
N HSQC and STD NMR experiments. The selected docking pose predicted the formation of π…

Controlling nuclease degradation of wireframe DNA origami with minor groove binders

EC Wamhoff, A Romanov, H Huang, BJ Read… - ACS …, 2022 - ACS Publications
Viruslike particles (VLPs) fabricated using wireframe DNA origami are emerging as promising
vaccine and gene therapeutic delivery platforms due to their programmable nature that …

[HTML][HTML] Multiplexed and high-throughput neuronal fluorescence imaging with diffusible probes

…, D Park, AB Kulesa, EC Wamhoff… - Nature …, 2019 - nature.com
E: cluster of conventional excitatory synapses with the presence of most synaptic markers;
I: cluster of possible inhibitory synapses with the absence of most synaptic markers; S: cluster …

In Situ Covalent Functionalization of DNA Origami Virus-like Particles

GA Knappe, EC Wamhoff, BJ Read, DJ Irvine… - ACS nano, 2021 - ACS Publications
… (E) AGE confirms structural integrity of nanostructures after functionalization and purification…
Most electronic Supporting Information files are available without a subscription to ACS Web …

[HTML][HTML] Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

EC Wamhoff, L Ronsard, J Feldman… - Nature …, 2024 - nature.com
… Briefly, SS320 E coli cells were transformed with the phI52 plasmid, based on the pUC19
vector, and the M13cp helper plasmid (generously provided by Andrew Bradbury, Los Alamos …

[HTML][HTML] Bioproduction of pure, kilobase-scale single-stranded DNA

TR Shepherd, RR Du, H Huang, EC Wamhoff… - Scientific Reports, 2019 - nature.com
… Here, we optimize growth conditions using an E. coli helper strain combined with a miniphage
genome carrying only an f1 origin and a β-lactamase-encoding (bla) antibiotic resistance …